|
IMMUNODEFICIENCY 32A
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
|
IMMUNODEFICIENCY 32A
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
IMMUNODEFICIENCY 32B
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Diffuse Large B-Cell Lymphoma
|
0.320 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also report that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
|
19525953 |
2009 |
|
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, IRF8 rs17445836G is associated with human autoimmune disease characterized by low-type I IFN levels, and this may have pharmacogenetic relevance as type I IFN is modulated in SLE and MS.
|
23965942 |
2013 |
|
Malignant neoplasm of breast
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Overall, we demonstrated that (a) Irf8-deficient mice generated myeloid populations highly homologous to tumor-induced MDSCs with respect to phenotype, function, and gene expression profiles; (b) IRF-8 overexpression in mice attenuated MDSC accumulation and enhanced immunotherapeutic efficacy; (c) the MDSC-inducing factors G-CSF and GM-CSF facilitated IRF-8 downregulation via STAT3- and STAT5-dependent pathways; and (d) IRF-8 levels in MDSCs of breast cancer patients declined with increasing MDSC frequency, implicating IRF-8 as a negative regulator in human MDSC biology.
|
24091328 |
2013 |
|
Diffuse Large B-Cell Lymphoma
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Subsequent screening for IRF8 by immunohistochemistry revealed IRF8 expression in 18/78 (23%), correlating with a germinal center B-cell-like (GCB) type of DLBCL.
|
23573829 |
2014 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, the evolution of Alox15 MPD to leukemia is associated with additional regulation of ICSBP on an RNA level, highlighting the potential usefulness of the Alox15 model for understanding the transition of CML to crisis.
|
17043146 |
2006 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased ICSBP expression is found in human AML and chronic myeloid leukemia during blast crisis (CML-BC).
|
19801548 |
2009 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since the expression of both the IRF8 and IRF4 genes is downregulated in CML patients, these results may add to our understanding of CML pathogenesis.
|
22003407 |
2011 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
More detailed analysis showed an absence of ICSBP-mRNA also in sorted B cells derived from CML patients.
|
9414265 |
1998 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate a significant correlation between the levels of IRF-8 and PML in these CML patients.
|
17189268 |
2007 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, coexpression of ICSBP and Bcr-Abl induced a transient B-lymphoproliferative disorder in the murine model of Bcr-Abl-induced CML-like disease.
|
10648600 |
2000 |
|
Myeloid Leukemia, Chronic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BCR-ABL-induced suppression of the transcription factor interferon regulatory factor 8 was previously proposed to block pDC development and compromise immune surveillance in CML.
|
30166420 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, IRF8 rs17445836G is associated with human autoimmune disease characterized by low-type I IFN levels, and this may have pharmacogenetic relevance as type I IFN is modulated in SLE and MS.
|
23965942 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, the impact of IRF8 expression on tumor growth could not be explained solely by its effects on regulating apoptotic response.
|
26008967 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, we found a positive correlation between ICSBP and TGF-β RI expression in several types of tumors using the cBioportal database.
|
30710564 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we showed that: 1) tumor growth was associated with a selective expansion of newly defined IRF8<sup>lo</sup> granulocyte progenitors (GPs); 2) tumor-derived GPs had an increased ability to form PMN-MDSCs; 3) tumor-derived GPs shared gene expression patterns with IRF8<sup>-/-</sup> GPs, suggesting that IRF8 loss underlies GP expansion; and 4) enforced IRF8 overexpression in vivo selectively constrained tumor-induced GP expansion.
|
28356386 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This screen identified a proviral integration that disrupts expression of the Interferon consensus sequence binding protein (ICSBP) tumor suppressor gene.
|
16939812 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Together, our results reveal a previously unrecognized role for IRF-8 expression in MDSC subset development, which may provide new avenues to target MDSCs in neoplasia.
|
24091328 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma.
|
31221219 |
2019 |
|
leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
When analyzed in four leukemia mRNA expression data sets, WT1 and IRF8 were anticorrelated.
|
20237505 |
2010 |
|
leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
|
22262849 |
2012 |
|
leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, the evolution of Alox15 MPD to leukemia is associated with additional regulation of ICSBP on an RNA level, highlighting the potential usefulness of the Alox15 model for understanding the transition of CML to crisis.
|
17043146 |
2006 |